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Research & Insights

Articles

Deep dives into the science of creatine, optimal dosing strategies, and the latest research findings.

Guides — 6 evergreen explainers

Written by hand on the questions that come up over and over: how much creatine to take, whether a loading phase is worth it, which form to buy, what the safety evidence actually shows, and why vegetarians respond more strongly. These are the articles that sit behind the calculators — every constant the dosing model uses is argued for in one of them.

Study write-ups — 13 papers covered

One newly published creatine paper at a time, read against its own abstract and then argued with. Each write-up sets out the design, reports what was found, and then says where the study is weak — small samples, unregistered endpoints, industry funding, conclusions that outrun the data. Coverage here is not endorsement, and several of these articles conclude that the paper they cover does not support what it claims.

How a study ends up here

Candidate papers are pulled from PubMed each week, passed through hard eligibility gates, and then scored against a published six-criterion rubric — design rigour, sample and power, effect size, novelty, population reach, and independence from the industry selling the product. The highest-scoring paper is the one written up. The rubric, its weightings and the model constants are set out in full on our research methodology page, and who writes these articles, where AI is used in producing them and what review they pass through before publication are covered in our editorial policy.

All
Aging
Athletic Performance
Brain Health
Clinical Trial
Cognition
Dosing
Guide
Mental Health
Musculoskeletal
New Research
Older Adults
Renal
Safety
Sleep
Sports Performance
Supplement Forms
Vegan
Women's Health
New Research
Musculoskeletal
Creatine and Resistance Training: A Comprehensive Meta-Analysis Confirming Established Muscle Benefits
This comprehensive meta-analysis of 63 studies confirms that combining creatine with resistance training significantly enhances muscle strength and lean mass.
September 28, 2026
New Research
Brain Health
Exploring the Cognitive Effects of Guanidinoacetic Acid (GAA) and Creatine
A new trial explores if combining guanidinoacetic acid (GAA) and creatine monohydrate improves cognition, but findings suggest only marginal benefits.
September 14, 2026
New Research
Brain Health
Scoping Review Highlights Preliminary Nature of Creatine for Dementia
This scoping review evaluates creatine supplementation for dementia, finding early mechanistic support but emphasizing a critical lack of human clinical trials.
September 7, 2026
New Research
Musculoskeletal
+1
Comparative Effects of Guanidinoacetic Acid (GAA) vs. Creatine in Older Adults
Discover how guanidinoacetic acid compares to creatine monohydrate for improving muscle strength and body composition in older adults without exercise.
August 31, 2026
Guide
Dosing
+1
How Much Creatine Should You Take? A Dosing Guide Based on Your Body
Why 5 g/day is the standard creatine dose, when your body size justifies more, and how lean mass, diet and daily turnover change the number you actually need.
August 28, 2026
New Research
Musculoskeletal
+1
Does a Multi-Ingredient Creatine and MCT Supplement Prevent Muscle Loss in Sarcopenia?
This eight-week RCT tested a multi-ingredient creatine supplement in older adults with sarcopenia. While muscle mass increased, the clinical impact was minimal.
August 28, 2026
Guide
Safety
+1
Creatine Side Effects and Safety: What the Evidence Actually Shows
Hair loss, kidney damage, cramping, bloating and weight gain — each common creatine concern traced back to the study that started it, and what replication found.
August 28, 2026
Guide
Dosing
+1
Do You Need a Creatine Loading Phase? Three Approaches Compared
Loading with 20 g/day saturates muscle in a week; 3 g/day takes about a month and ends up in the same place. Here is how to choose, and a third option.
August 28, 2026
Guide
Supplement Forms
+1
Creatine Monohydrate vs. HCL vs. Kre-Alkalyn: Which Form Is Worth Buying?
Six creatine forms compared on evidence, absorption and cost. Monohydrate wins on all three, and the marketing claims behind the alternatives rarely survive testing.
August 28, 2026
Guide
Vegan
+1
Creatine for Vegans and Vegetarians: Why the Response Is Larger
Plant-based diets supply almost no dietary creatine, leaving muscle stores roughly 10% lower. That gap is why vegans often respond more strongly to supplementation.
August 28, 2026
Guide
Brain Health
+1
Creatine and Brain Health: What the Cognitive Evidence Supports
Creatine buffers energy in the brain as well as muscle. Here is where the cognitive evidence is solid, where it is preliminary, and where it is still only a hypothesis.
August 28, 2026
New Research
Brain Health
+1
Can a Single Dose of Creatine Protect Your Brain During Sleep Deprivation?
A 2026 crossover trial finds a single 0.2 g/kg dose of creatine reduces cognitive decline during 21 hours of sleep deprivation, with gains of up to 12%.
August 23, 2026
New Research
Vegan
+1
Does Creatine Boost Power for Vegans? A Look at Recent Research
A triple-blind trial in 20 vegan adults finds four weeks of creatine improved body composition and jump power, but changed neither strength nor sprints.
August 21, 2026
New Research
Renal
+1
Intradialytic Creatine Supplementation in Hemodialysis
A 2026 randomised placebo-controlled pilot study testing whether creatine delivered through the dialysate can safely raise creatine levels in dialysis.
August 5, 2026
New Research
Mental Health
+1
Reprogramming Brain Bioenergetics in Depression
A 2026 integrative framework exploring how creatine, BCAAs, and physical exercise may support brain bioenergetics and depression-related outcomes. No new data.
August 4, 2026
New Research
Musculoskeletal
+1
Short-Term Creatine Supplementation in Resistance-Trained Athletes
A crossover trial in ten trained men finds creatine raised repetitions and bar velocity from two hours after the first dose, with mixed cardiovascular effects.
January 24, 2026
New Research
Older Adults
+2
Creatine Supplementation and the Muscle-Brain Axis in Aging
A narrative review of the muscle-brain axis, assessing how creatine combined with resistance training affects strength, lean mass and cognition in ageing.
January 12, 2026